European Association for Palliative Care

Forum.

Table 2. Use of drugs for ‘sudden’ sedation.

 

Study
P = prospective
R = retrospective

 

Sample size, setting and country

 

Frequency of sedation (%)

 

Drugs used (%, where stated)

 

Indications for sedation
(%, where stated)

 

Fainsinger 20005

P

 

387
PCU
Canada

 

15–36

Midazolam                
Haloperidol                  
Lorazepam                   
Phenobarbital     
Levomepromazine    

71
9
8
3
1

Delirium                  
Dyspnoea              
Pain                           
Existential distress

61
26
7
7

 

Fainsinger 200016

P

 

150
PCU + Hospital
Canada

 

4–10

Midazolam               
Levomepromazine 
Lorazepam               
Diazepam                  

50
30
10
10

Delirium     
Dyspnoea

91
9

 

Fainsinger 199817

R

 

278
PCU
Canada

 

1

Midazolam        

100

Delirium  

100

PCU = Palliative Care Unit

(Interesting that all the studies in this table are from the same author – is Robin the only one practising sudden sedation?!?  I also am intrigued to see that in the 1998 study he used midazolam to sedate for delirium, in contradiction to your text comment about not using a benzodiazepine alone for delirium)

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