Background: Opioid receptors located on peripheral sensory nerve are responsible for local analgesic effect of exogenous opioid agonists applied on the inflammated skin. First impulse that we started our investigations about gels and ointments containing opioids was that there are no pharmaceutical preparations in pharmacies which can be locally administrated and there were no information about bases for them. We tried at first elementary initiation of our study to estimate optimal composition of bases for ointments containing morphine sulphate and morphine hydrochloride.
Material and Methods: In a prescription proceeding mode there were developed preparations for transdermal application hydrogel and ointment of an absorption cream with a transdermal transition promotors of morphine sulphate content ~ 0.2% and morphine hydrochloride 0.225%. The preparations were studied by a rheological adhesives, tixotropy, hydrogen ion activity (aH+, pH), practical density and influence of transdermal transition promoters on the diffusion slow kinetics of morphine sulphate and morphine hydrochloride.
Results and Conclusions: Investigations shows, according to the interaction between morphine sulphate, morphine hydrochloride and different base compositions, that we receive different rheological adhesives of preparations. The kinetic of releasing morphine sulphate was faster in all preparations than morphine hydrochloride. Acidity (pH) levels in developed substances were included in physiological tolerance limits of skin and mucosal.