Advances in medicine have greatly improved the possibilities to treat seriously ill patients and to prolong life or postpone death. Hence, physicians are more than ever confronted with end-of-life decisions (ELDs). It is, however, to a large extent unknown to what degree practices in the field of medical decision-making at the end of life vary in Europe. We performed an empirical study of end-of-life decision-making in 6 European countries: Belgium (Flanders), Denmark, Italy (four areas), the Netherlands, Sweden and Switzerland (German speaking part). 20,480 deaths have been studied and 8,585 physicians participated to an attitude questionnaire. End-of-life decisions are understood to include decisions about whether or not to withhold or withdraw potentially life-prolonging treatment, e.g. mechanical ventilation, tube-feeding, dialysis; decisions about the alleviation of pain or other symptoms with, e.g., opioids, benzodiazepines or barbiturates in dosages large enough to hasten death as a possible or certain side effect; and decisions about euthanasia or physician-assisted suicide, which are in our study defined as the administration, prescription or supply of drugs to end life at the patient’s explicit request. The workshop will present the robust empirical data of this European study. The main topics of the four presentations are palliative care and end of life decision making: (1) Endof- life decision-making in 6 European countries: determinants of intended behaviour, (2) Education in palliative care and experiences of end-of-life decisions, (3) Potentially life-shortening drugs used for alleviation of pain and symptoms in end-of-life care, and (4) Terminal sedation and end of life decisions. The discussion will be introduced by two referents.